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Inhalt
Our clinical research addresses unresolved problems in vascular medicine by combining deeply characterized patient cohorts, advanced vascular imaging, biomarkers and prospective clinical studies. We aim to understand why vascular disease develops and recurs, identify patients at risk and translate mechanistic insights into better diagnosis, prevention and treatment.
1. Blood Flow, Vascular Disease and Precision Ultrasound
Why do some arteries develop recurrent disease after apparently successful revascularization?
Clinical Problem
Patients with peripheral arterial disease frequently require revascularization to restore blood flow. However, successful revascularization does not always result in durable vascular recovery, and restenosis remains an important clinical problem. Conventional vascular ultrasound primarily assesses stenosis and blood-flow velocities but provides limited information about the local hemodynamic forces acting on the vessel wall.
Our Approach
We combine prospective clinical studies in patients with peripheral arterial disease with conventional duplex ultrasound and high-frame-rate vector flow imaging (VFI). We characterize blood-flow direction and velocity, volume flow, wall shear stress and oscillatory shear index before and after vascular interventions.
What We Have Already Shown
Our initial work demonstrated the feasibility of VFI in the femoropopliteal arteries of patients with PAD. We subsequently demonstrated measurable changes in blood volume flow and wall shear stress following iliac or femoropopliteal revascularization.
Next Steps & Clinical Impact
We now want to determine whether these hemodynamic parameters can help predict restenosis, identify patients who may benefit from closer surveillance and ultimately enable more individualized treatment monitoring.
Key Publications
J Ultrasound Med. 2026
Prüser JL, Winkelbauer G, Dieker W, Adler A, Amendt K, Sigl M. Pre- and Post-Interventional Hemodynamic Characterization of the Femoropopliteal Artery Using Vector Flow Imaging in Peripheral Arterial Occlusive Disease. J Ultrasound Med. 2026;45:1397–1407. doi:10.1002/jum.70176.
Vasa. 2023
Shchetynska-Marinova T, Gerdes L, Hohneck AL, Winter L, Amendt K, Schwenke K, Gerken ALH, Du Y, Dürschmied D, Sigl M. First experiences of ultrasound vector flow imaging at the femoropopliteal artery in peripheral arterial disease. Vasa. 2023;52:394–401. doi:10.1024/0301-1526/a001095.
