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Ausgewählte Publikationen

Vogel, S., Magerl, W., Treede, R. D., & Schilder, A. (2022). Dose-Dependent Pain and Pain Radiation after Chemical Stimulation of the Thoracolumbar Fascia and Multifidus Muscle: A Single-Blinded, Cross-Over Study Revealing a Higher Impact of Fascia Stimulation. Life (Basel), 12(3). https://doi.org/10.3390/life12030340

Singaravelu, S. K., Goitom, A. D., Graf, A. P., Moerz, H., Schilder, A., Hoheisel, U., Spanagel, R., & Treede, R. D. (2022). Persistent muscle hyperalgesia after adolescent stress is exacerbated by a mild-nociceptive input in adulthood and is associated with microglia activation. Sci Rep, 12(1), 18324. https://doi.org/10.1038/s41598-022-21808-x

Schwarz, M. L. R. (2022). [Oedipus, a traumatological - orthopaedic case? - Essay on an unfortunate figure from antiquity]. Z Orthop Unfall, 160(4), 369-376. https://doi.org/10.1055/a-1844-5446 (Odipus, ein traumatologisch - orthopadischer Fall?)

Schwarz, M. L., Reisig, G., Schneider-Wald, B., Weiss, C., Hauk, L., & Schutte, A. (2022). Coefficient of Friction and Height Loss: Two Criteria Used to Determine the Mechanical Property and Stability of Regenerated Versus Natural Articular Cartilage. Biomedicines, 10(11). https://doi.org/10.3390/biomedicines10112685

Nochi, Z., Pia, H., Bloms-Funke, P., Boesl, I., Caspani, O., Chapman, S. C., Fardo, F., Genser, B., Goetz, M., Kostenko, A. V., Leone, C., Li, T., Mouraux, A., Pelz, B., Pogatzki-Zahn, E., Schilder, A., Schnetter, E., Schubart, K., Stouffs, A., . . . Treede, R. D. (2022). IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET). Trials, 23(1), 163. https://doi.org/10.1186/s13063-022-06087-1

Leone, C., Di Stefano, G., Di Pietro, G., Bloms-Funke, P., Boesl, I., Caspani, O., Chapman, S. C., Finnerup, N. B., Garcia-Larrea, L., Li, T., Goetz, M., Mouraux, A., Pelz, B., Pogatzki-Zahn, E., Schilder, A., Schnetter, E., Schubart, K., Tracey, I., Troconiz, I. F., . . . Treede, R. D. (2022). IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity. Trials, 23(1), 739. https://doi.org/10.1186/s13063-022-06431-5

Magerl, W., Thalacker, E., Vogel, S., Schleip, R., Klein, T., Treede, R. D., & Schilder, A. (2021). Tenderness of the Skin after Chemical Stimulation of Underlying Temporal and Thoracolumbar Fasciae Reveals Somatosensory Crosstalk between Superficial and Deep Tissues. Life (Basel), 11(5). https://doi.org/10.3390/life11050370

Engelhardt, J. P., Schutte, A., Hetjens, S., Reisig, G., & Schwarz, M. L. (2021). Resilience to height loss of articular cartilage of osteoarthritic stifle joints of old pigs, compared with healthy cartilage from young pigs in a tribological pin-on-plate exposure, revealing similar friction forces. PLoS One, 16(4), e0250244. https://doi.org/10.1371/journal.pone.0250244

Schutte, A., Mack, M., Behler, H., Ruland, M., Weiss, C., & Schwarz, M. L. R. (2020). Tribometer for measuring coefficients of friction of uneven surfaces like articular cartilage. Rev Sci Instrum, 91(3), 034102. https://doi.org/10.1063/1.5124006

Gamez, C., Schneider-Wald, B., Schuette, A., Mack, M., Hauk, L., Khan, A. U. M., Gretz, N., Stoffel, M., Bieback, K., & Schwarz, M. L. (2020). Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results. PLoS One, 15(1), e0227553. https://doi.org/10.1371/journal.pone.0227553

Gamez, C., Schneider-Wald, B., Bieback, K., Schuette, A., Buttner, S., Hafner, M., Gretz, N., & Schwarz, M. L. (2020). Compression Bioreactor-Based Mechanical Loading Induces Mobilization of Human Bone Marrow-Derived Mesenchymal Stromal Cells into Collagen Scaffolds In Vitro. Int J Mol Sci, 21(21). https://doi.org/10.3390/ijms21218249

Schwarz, M. L., Reisig, G., Schutte, A., Becker, K., Serba, S., Forsch, E., Thier, S., Fickert, S., Lenz, T., Weiss, C., Hetjens, S., Bludau, F., Bothe, F., Richter, W., & Schneider-Wald, B. (2019). Report on a large animal study with Gottingen Minipigs where regenerates and controls for articular cartilage were created in a large number. Focus on the conditions of the operated stifle joints and suggestions for standardized procedures. PLoS One, 14(12), e0224996. https://doi.org/10.1371/journal.pone.0224996

Pfau, D. B., Greffrath, W., Schilder, A., Magerl, W., Ohler, C., Westermann, A., Maier, C., Doppler, K., Sommer, C., Orth, M., Hammes, H. P., Kurz, J., Gotz, M., Treede, R. D., & Schuh-Hofer, S. (2019). Technical and clinical performance of the thermo-test device "Q-Sense" to assess small fibre function: A head-to-head comparison with the "Thermal Sensory Analyzer" TSA in diabetic patients and healthy volunteers. Eur J Pain, 23(10), 1863-1878. https://doi.org/10.1002/ejp.1461

Schilder, A. (2019). Changes of pain sensitivity and differences in the quality of pain between fascia tissue and muscle tissue of the lower back in human. Manuelle Medizin, 57(1), 48-50. https://doi.org/10.1007/s00337-019-0505-y

Haroun, O. M. O., Vollert, J., Lockwood, D. N., Bennett, D. L. H., Pai, V. V., Shetty, V., Wakade, A. V., Khodke, A. S., Schilder, A., Pfau, D., Enax-Krumova, E. K., Maier, C., Treede, R. D., & Rice, A. S. C. (2019). Clinical characteristics of neuropathic pain in leprosy and associated somatosensory profiles: a deep phenotyping study in India. Pain Rep, 4(6), e743. https://doi.org/10.1097/PR9.0000000000000743

Mack, M. (2019). Vergleich Impedanzregelung (IC) – Parallele Impedanzregelung (PIC) zur Kraft-/Impedanzregelung dynamischer Systeme. at - Automatisierungstechnik67(4), 337-358. https://doi.org/10.1515/auto-2018-0049

Schilder, A., Magerl, W., Klein, T., & Treede, R. D. (2018). Assessment of pain quality reveals distinct differences between nociceptive innervation of low back fascia and muscle in humans. Pain Rep, 3(3), e662. https://doi.org/10.1097/PR9.0000000000000662

Lingner, M., Seidling, R., Lehmann, L. J., Mauermann, E., Obertacke, U., & Schwarz, M. L. R. (2018). Osseointegrative effect of rhBMP-2 covalently bound on a titan-plasma-spray-surface after modification with chromosulfuric acid in a large animal bone gap-healing model with the Gottingen minipig. J Orthop Surg Res, 13(1), 219. https://doi.org/10.1186/s13018-018-0915-x

Seidling, R., Lehmann, L. J., Lingner, M., Mauermann, E., Obertacke, U., & Schwarz, M. L. (2016). Analysis of the osseointegrative force of a hyperhydrophilic and nanostructured surface refinement for TPS surfaces in a gap healing model with the Gottingen minipig. J Orthop Surg Res, 11(1), 119. https://doi.org/10.1186/s13018-016-0434-6

Schilder, A., Magerl, W., Hoheisel, U., Klein, T., & Treede, R. D. (2016). Electrical high-frequency stimulation of the human thoracolumbar fascia evokes long-term potentiation-like pain amplification. Pain, 157(10), 2309-2317. https://doi.org/10.1097/j.pain.0000000000000649

Reisig, G., Kreinest, M., Richter, W., Wagner-Ecker, M., Dinter, D., Attenberger, U., Schneider-Wald, B., Fickert, S., & Schwarz, M. L. (2016). Osteoarthritis in the Knee Joints of Gottingen Minipigs after Resection of the Anterior Cruciate Ligament? Missing Correlation of MRI, Gene and Protein Expression with Histological Scoring. PLoS One, 11(11), e0165897. https://doi.org/10.1371/journal.pone.0165897

Kreinest, M., Reisig, G., Strobel, P., Fickert, S., Brade, J., Wennemuth, G., Lipp, P., & Schwarz, M. L. (2016). Analysis of Gene Expression and Ultrastructure of Stifle Menisci from Juvenile and Adult Pigs. Comp Med, 66(1), 30-40. https://www.ncbi.nlm.nih.gov/pubmed/26884408

Kreinest, M., Reisig, G., Strobel, P., Dinter, D., Attenberger, U., Lipp, P., & Schwarz, M. (2016). A Porcine Animal Model for Early Meniscal Degeneration - Analysis of Histology, Gene Expression and Magnetic Resonance Imaging Six Months after Resection of the Anterior Cruciate Ligament. PLoS One, 11(7), e0159331. https://doi.org/10.1371/journal.pone.0159331

Schwarz, M. L., Schneider-Wald, B., Brade, J., Schleich, D., Schutte, A., & Reisig, G. (2015). Instruments for reproducible setting of defects in cartilage and harvesting of osteochondral plugs for standardisation of preclinical tests for articular cartilage regeneration. J Orthop Surg Res, 10, 117. https://doi.org/10.1186/s13018-015-0257-x

Schilder, A., Hoheisel, U., Magerl, W., Benrath, J., Klein, T., & Treede, R. D. (2014a). Sensory findings after stimulation of the thoracolumbar fascia with hypertonic saline suggest its contribution to low back pain. Pain, 155(2), 222-231. https://doi.org/10.1016/j.pain.2013.09.025

Schilder, A., Hoheisel, U., Magerl, W., Benrath, J., Klein, T., & Treede, R. D. (2014b). [Deep tissue and back pain: stimulation of the thoracolumbar fascia with hypertonic saline]. Schmerz, 28(1), 90-92. https://doi.org/10.1007/s00482-013-1373-3 (Tiefe Gewebe und Ruckenschmerzen : Reizung der Fascia thoracolumbalis durch hypertone Kochsalzlosung.)

Brenke, C., Pott, P., Schwarz, M. L., Schmieder, K., & Barth, M. (2014). Development of a low-cost polymethylmethacrylate stand-alone cervical cage: technical note. J Neurol Surg A Cent Eur Neurosurg, 75(4), 317-322. https://doi.org/10.1055/s-0034-1368686

Schneider-Wald, B., von Thaden, A. K., & Schwarz, M. L. (2013). [Defect models for the regeneration of articular cartilage in large animals]. Orthopade, 42(4), 242-253. https://doi.org/10.1007/s00132-012-2044-2 (Defektmodelle fur die Gelenkknorpelregeneration im Grosstier.)

Kirsch, S., Kreinest, M., Reisig, G., Schwarz, M. L., Strobel, P., & Schad, L. R. (2013). In vitro mapping of 1H ultrashort T2* and T2 of porcine menisci. NMR Biomed, 26(9), 1167-1175. https://doi.org/10.1002/nbm.2931

Schwarz, M. L., Schneider-Wald, B., Krase, A., Richter, W., Reisig, G., Kreinest, M., Heute, S., Pott, P. P., Brade, J., & Schutte, A. (2012). [Tribological assessment of articular cartilage. A system for the analysis of the friction coefficient of cartilage, regenerates and tissue engineering constructs; initial results]. Orthopade, 41(10), 827-836. https://doi.org/10.1007/s00132-012-1951-6 (Tribologische Messungen am Gelenkknorpel. Ein Prufstand zur Messung der Reibungszahlen von Knorpel gegen Knorpel, Regeneraten und TE-Konstrukten und erste Ergebnisse.)

Schreiner, U., Schulze, A., Scheller, G., Apruzzese, C., & Schwarz, M. L. (2012). [Osseointegration of ceramic cement-free acetabular cups]. Z Orthop Unfall, 150(1), 32-39. https://doi.org/10.1055/s-0031-1280030 (Osteointegration zementfreier Huftpfannen aus Keramik.)

Pott, P. P., Schwarz, M. L., Gundling, R., Nowak, K., Hohenberger, P., & Roessner, E. D. (2012). Mechanical properties of mesh materials used for hernia repair and soft tissue augmentation. PLoS One, 7(10), e46978. https://doi.org/10.1371/journal.pone.0046978

Lehmann, L. J., Werner, A., Dinter, D. J., Mauermann, E., Seidling, R., Brade, J., Laub, M., Luers, S., Madenci, S., Jennissen, H., Obertacke, U., Scharf, H. P., & Schwarz, M. L. (2011). Scintigraphic evaluation of rhBMP-2-biocoated implants reveals no ectopic bone formation. Biomed Pharmacother, 65(1), 63-68. https://doi.org/10.1016/j.biopha.2010.10.008

Pott, P. P., Kamping, S., Bomba, I. C., Diesch, E., Flor, H., & Schwarz, M. L. (2010). An MR-compatible device for automated and safe application of laser stimuli in experiments employing nociceptive stimulation. J Neurosci Methods, 186(1), 1-7. https://doi.org/10.1016/j.jneumeth.2009.10.014

Schwarz, M. L., Kowarsch, M., Rose, S., Becker, K., Lenz, T., & Jani, L. (2009). Effect of surface roughness, porosity, and a resorbable calcium phosphate coating on osseointegration of titanium in a minipig model. J Biomed Mater Res A, 89(3), 667-678. https://doi.org/10.1002/jbm.a.32000

Schwarz, M. L., Witt, S. H., Schneider-Wald, B., Buettner, A., Witt, C. C., Stoeve, J., Scharf, H. P., Labeit, S., & Milz, S. (2008). Titin expression in human articular cartilage and cultured chondrocytes: a novel component in articular cartilage biomechanical sensing? Biomed Pharmacother, 62(5), 339-347. https://doi.org/10.1016/j.biopha.2007.08.003

Pott, P. P., & Schwarz, M. L. (2007). [The relation of workspace and installation space of epicyclic kinematics with six degrees of freedom]. Biomed Tech (Berl), 52(5), 323-336. https://doi.org/10.1515/BMT.2007.055 (Das Verhaltnis von Arbeitsraum zu Bauraum epizyklischer Kinematiken mit sechs Freiheitsgraden.)

Stove, J., Schneider-Wald, B., Scharf, H. P., & Schwarz, M. L. (2006). Bone morphogenetic protein 7 (bmp-7) stimulates proteoglycan synthesis in human osteoarthritic chondrocytes in vitro. Biomed Pharmacother, 60(10), 639-643. https://doi.org/10.1016/j.biopha.2006.09.001

Schwarz, M. L., Kogel, A., Claus, A. M., & Scharf, H. P. (2006). Accuracy of Ein Bild Rontgen Analyse in determining wear in total hip arthroplasty in vitro. Clin Orthop Relat Res, 445, 197-203. https://doi.org/10.1097/01.blo.0000203461.97511.e2