Quantitative MR-Bildgebung

Die Arbeitsgruppe Neurologische MRT-Bildgebung beschäftigt sich mit der Anwendung und Weiterentwicklung neuer MR Methoden bei unterschiedlichen Erkrankungen des zentralen Nervensystems mit den Schwerpunkten Multiple Sklerose und akuter Schlaganfall.

• Diffusionsgewichtete Bildgebung
• DTI / TBSS
• Natrium (23Na) MRT
• Arterial Spin Labelling (ASL) Perfusionsimaging
• Gradienten-Echo Bildgebung (SWI, T2*)
• Hirnatrophieanalysen
• Voxel-Based-Morphometry (VBM)
• Suszeptibilitätsgewichtete Bildgebung

Ausgewählte Publikationen

• Eisele P, Szabo K, Alonso A, Ong M, Platten M, Schoenberg SO, Gass A. Lack of T1 hyperintensity in the dentate nucleus after 15 administrations of a macrocyclic contrast agent in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2018 Mar; 89(3): 324-326
• Eisele P, Szabo K, Ebert A, Brueck W, Platten M, Gass A. Spatiotemporal evolution of venous narrowing in acute MS lesions. Neurol Neuroimmunol Neuroinflamm March 2018; 5: e440    
• Eisele P, Szabo K, Ebert A, Platten M, Gass A. Brain atrophy in natalizumab-treated patients with multiple sclerosis: A five-year retrospective study. J Neuroimaging 2019 Mar; 29(2): 190-192
• Eisele P, Konstandin S, Szabo K, Ebert A, Roßmanith C, Paschke N, Kerschensteiner M, Platten M, Schoenberg SO, Schad LR, Gass A. Temporal evolution of acute multiple sclerosis lesions on serial sodium (²³Na) MRI. Mult Scler Relat Disord 2019 Apr; 29: 48-54
• Eisele P, Szabo K, Ebert A, Radbruch A, Platten M, Schoenberg SO, Gass A. Diffusion-weighted imaging of the dentate nucleus after repeated application of gadolinium-based contrast agents in multiple sclerosis. Magn Reson Imaging 2019 May; 58: 1-5
• Eisele P, Fischer K, Szabo K, Platten M, Gass A. Characterization of contrast-enhancing and non contrast-enhancing Multiple Sclerosis lesions with susceptibility-weighted imaging. Front. Neurol. 10: 1082.
• Weber CE, Sandikci V, Ebert A, Szabo K, Platten M, Gass A, Eisele P. Investigation of the “central vein sign“ in infratentorial multiple sclerosis lesions. Mult Scler Relat Disord in press. DOI: https://doi.org/10.1016/j.msard.2020.102409

• Weber CE, Ebert A, Platten M, Gass A, Eisele P. Susceptibility-weighted 3T MRI of the swallow tail sign in multiple sclerosis: a case control study. J   Neuroimaging in press

• Eisele P, Szabo K, Griebe M, Rossmanith C, Förster A, Hennerici M, Gass A. Reduced diffusion in a subset of acute MS lesions: a serial multiparametric MRI study. AJNR Am J Neuroradiol. 2012 Aug; 33(7): 1369-1373.

• Eisele P, Szabo K, Griebe M, Wolf ME, Hennerici MG, Gass A. Cerebrospinal fluid pleocytosis in multiple sclerosis patients with lesions showing reduced diffusion. Mult Scler. 2014 Sep; 20(10): 1391-1395.

• Eisele P, Griebe M, Szabo K, Wolf ME, Alonso A, Engelhardt B, Hennerici MG, Gass A. Investigation of Leptomeningeal Enhancement in MS - A post-contrast FLAIR MRI study. Neurology. 2015 Feb 24; 84(8): 770-775

• Alonso A*, Eisele P*, Ebert A, Griebe M, Engelhardt B, Szabo K, Hennerici MG, Gass A. Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis. Neurol Neuroimmunol Neuroinflamm December 2015 vol. 2 no. 6 e164

• Eisele P, Alonso A, Griebe M, Szabo K, Hennerici MG, Gass A. Investigation of cerebral microbleeds in multiple sclerosis as a potential marker of blood-brain-barrier dysfunction. Mult Scler Relat Disord. 2016 May; 7:61-64

• Eisele P, Konstandin S, Griebe M, Szabo K, Wolf ME, Alonso A, Ebert A, Serwane J, Rossmanith C, Hennerici MG, Schad LR, Gass A. Heterogeneity of acute multiple sclerosis lesions on sodium (²³Na) MRI. Mult Scler. 2016 Jul; 22(8): 1040-1047.

• Eisele P, Alonso A, Szabo K, Ebert A, Ong M, Schoenberg SO, Gass A. Lack of increased signal intensity in the dentate nucleus after repeated administration of a macrocyclic contrast agent in multiple sclerosis: An observational study. Medicine (Baltimore) 2016; 95: e4624.

• Eisele P, Konstandin S, Szabo K, Ong M, Zöllner F, Schad LR, Schoenberg SO, Gass A. Sodium MRI of T1 high signal intensity in the dentate nucleus due to gadolinium deposition in multiple sclerosis. J Neuroimaging. 2017 Jul; 27 (4): 372-375.

• Rocca MA, Valsasina P, Meani A, Gobbi C, Zecca C, Rovira A, Montalban X, Kearney H, Ciccarelli O, Matthews L, Palace J, Gallo A, Bisecco A, Gass A, Eisele P, Lukas C, Bellenberg B, Barkhof F, Vrenken H, Preziosa P, Comi G, Filippi M, for the MAGNIMS study group. Clinically relevant cranio-caudal patterns of cervical atrophy evolution in MS. Neurology, 2019; 93 (20): e1852–e1866.

• Popescu V, Agosta F, Hulst HE, Sluimer IC, Knol DL, Sormani MP, Enzinger C, Ropele S, Alonso J, Sastre-Garriga J, Rovira A, Montalban X, Bodini B, Ciccarelli O, Khaleeli Z, Chard DT, Matthews L, Palace J, Giorgio A, De Stefano N, Eisele P, Gass A, Polman CH, Uitdehaag BM, Messina MJ, Comi G, Filippi M, Barkhof F, Vrenken H; on behalf of the MAGNIMS Study Group. Brain atrophy and lesion load predict long term disability in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2013 Oct; 84(10): 1082-1091
• Fox J, Kraemer M, Schormann T, Dabringhaus A, Hirsch J, Eisele P, Szabo K, Weiss C, Amann M, Weier K, Naegelin Y, Kappos L, Gass A. Individual assessment of brain tissue changes in MS. The effect of focal lesions on short term focal atrophy development in MS. A Voxel-Guided Morphometry study. Int. J. Mol. Sci. 2016, 17, 489
• Eisele P, Szabo K, Hornberger E, Griebe M, Hennerici MG, Kieseier BC, Gass A. Presumptive Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis after Natalizumab Therapy. J Neuroimaging. 2014 Jul;24(4):425-428

• Eisele P, Gass A, Alonso A, Wolf ME, Griebe M, Szabo K. Susceptibility weighted MRI signs of compensatory mechanism in non-convulsive status epilepticus. Neurology. 2016 Jul 5;87(1):116-117

• Eisele P, Alonso A, Szabo K, Gass A. Reduced diffusion in acute cervical cord multiple sclerosis lesions. Neurology Clin Pract 2017;7:401-403.

• Gass A, Rocca MA, Agosta F, Ciccarelli O, Chard D, Valsasina P, Brooks JC, Bischof A, Eisele P, Kappos L, Barkhof F, Filippi M, MAGNIMS Study Group. Spinal cord pathology in MS visualized by MRI - new opportunities for monitoring disease progression. Lancet Neurol. 2015 Apr; 14(4): 443-454